职务：普通妇科主任兼妇二科主任

教授职称：博士生导师

学术或社会头衔：

1、中华预防医学会生殖健康分会常委

2、浙江省预防医学会生殖健康专业委员会主任委员

3、浙江省医学会微创外科学分会副主任委员

4、中国医师协会妇产科分会子宫内膜异位症专业委员会副主任委员

5、中国医师协会微无创专委会盆底与盆腔疼痛专业委员会主任委员

6、全国卫生产业管理协会妇科智能诊疗分会副会长

7、中国医药教育协会妇科专业委员会副主任委员

8、中国性学会妇科专业委员会副主任委员

9、浙江省数理医学学会盆腔整合医学专业委员会主任委员

10、浙江省医学会妇产科分会子宫内膜异位症学组副组长

11、《中华妇产科杂志》通讯编委

详细介绍：
1989年浙江大学医学院医学系（原浙江医科大学临床医学系），毕业留校分配在浙江大学医学院附属妇产科医院，一直从事妇产科临床、教学及科研工作，积累了丰富的临床经验。1994年获妇产科学临床妇科子宫内膜异位症专业硕士学位。在国内首先关注子宫内膜异位症伴有高泌乳素血症现象，并作为临床子宫内膜异位症诊断的参考指标。2011年获得博士学位。1998年4月至1999年7月作为访问学者相继在美国West Virginia University分子病理实验室和M.D.Anderson Cancer Center分子流行病实验室从事分子生物学、分子流行病学及实验临床转化研究工作。回国后专项从事子宫内膜异位症的基础和临床研究工作。2003年作为访问学者在澳大利亚Quensland University Adult Hospital专项从事妇科内窥镜的临床工作。了解国内外子宫内膜异位症和妇科内窥镜的前沿研究发展动态，对子宫内膜异位症的诊断和治疗已经形成一个系统的诊疗流程。参与全国子宫内膜异位症诊治规范的制订。较早开展主要引起患者临床疼痛症状的深部浸润型子宫内膜异位症的腹腔镜手术，取得较高的疗效。已熟练掌握妇科内镜各种手术技术包括腹腔镜下子宫广泛性子宫全切术加盆腔淋巴结切除术。近年来作为主要参与者获得浙江省科技进步奖二等奖和国家教育部科技进步奖二等奖各1项，首创子宫腺肌病双瓣法保守性手术治疗子宫腺肌症，获得满意的疗效，并获得浙江省医药卫生科技奖一等奖1项。2020年获浙江省科学技术自然奖二等奖。2011年起负责浙江省重点医学（创新）微创妇科学，主持国家自然基金7项和科技部重大专项课题2项，目前在研课题2项。共发表论文超过140篇，其中SCI源期刊发表超过80篇。主编由人民卫生出版社的《子宫腺肌症》（2018，58万字），主译由中国科学技术出版社的(《Endometriosis: Current topics in Diagnosis and Management》原著Nazar N. Amso and Banerjee)(2024.7; 36.6万字)。参与《子宫内膜异位症》、《宫颈疾病学》、《外阴阴道疾病》和《异位妊娠》等参考书的编写。

主要学术任职及学术成果：

一、发表论文：

1、英文期刊

1.Wang J, Mao X, Zhu L, Zhang X. Unravelling the Intricate Link: Mast Cells and Estrogen-Induced Pain Sensitization in Endometriosis. Int J Biol Sci. 2025 Sep 21;21(13):5891-5904.[通信作者] (IF: 10.00)

2.Li W, Zheng C, Sun X, Lv W, Zhang X. Curcumin modulates oxidative stress via NOX4 to ameliorate endometrial hyperplasia. Int Immunopharmacol. 2025 Aug 19;164:115392.[通信作者] (IF: 4.7)

3.Sun M, Wang J, Xu P, Zhu L, Zou G, Chen S, Liu Y, Zhang X. Development and validation of MRI-based radiomics model for clinical symptom stratification of extrinsic adenomyosis. Ann Med. 2025 Dec;57(1):2534521.[通信作者] (IF: 4.3)

4.Mao X, Wang J, Ding S, Guo X, Xu X, Xu P, Zhang X. MRGPRX2 Mediates Mast Cell-Induced Endometriosis Pain Through the Sensitization of Sensory Neurons via Histamine/HRH1/TRPV1 Signaling Pathway. FASEB J. 2025 Jul 15;39(13):e70778.[通信作者] (IF: 4.2)

5.Ding S, Mao X, Zhu L, Xu X, Chen S, Zou G, Xu P, Wang J, Zhang X. CCL2/CCR4 participates in mast cell-mediated epithelial mesenchymal transition in endometriosis. Reproductive BioMedicine Online. 17 January 2025, 104796. [通信作者] (IF: 3.7)

6.Yin M, Wang J, Zhang X. Immune infiltration related circular RNA, circGLIS2, facilitated progression of endometriosis through miR-4731-5p/IL-1β axis. Int J Biol Macromol. 2024;281(Pt2):136318. [通信作者] (IF: 7.7)

7.Peng Y, Ding S, Xu P, Zhang X, Wang J, Li T, Liao L, Zhang X. CCL18 promotes endometriosis by increasing endometrial cell migration and neuroangiogenesis. European Journal of Histochemistry 2024; volume 68:4052. [通信作者] (IF: 2.1)

8.Xu P, He X, Zhang Y, Wang Y, Zou G, Wang J, Zhang X. Perinatal Outcomes were Associated with the Positional Relationship between Placenta and Adenomyotic Lesion in Pregnant Patients with Adenomyosis. Clin. Exp. Obstet. Gynecol. 2024; 51(1):1-10. [通信作者] (IF: 0.2)

9.Fang Z, Wang J, Li T, Yin M, Peng Y, Zhang X. A method for isolating and culturing ectopic epithelial and stromal cells to study human adenomyosis. Arch Gynecol Obstet. 2024;309(2):551-563 [通信作者] (IF: 2.6) 

10.Yu Q, Chen L, Wang J, Xu X, Li T, Guo X, Yin M, Mao X, Zhu L, Zou G, Liu Y, Zhang X. Investigation of the therapeutic effect of salbutamol on endometriosis in a mouse model. Reprod Sci. 2024;31(2):430-440. [通信作者] (IF: 2.9/Q3)

11.Yin M, Wang J, Ying X, Fang Z, Zhang X. Long non coding RNA, C8orf49, a novel diagnostic and prognostic biomarker, enhances PTEN/FZD4-mediated cell growth and metastasis by sponging miR-1323 in endometriosis. Mol Cell Endocrinol. 2023;575:112040. [通信作者] (IF: 4.1)

12.Che X, Wang J, Sun W, He J, Wang Q, Zhu D, Zhu W, Zhang J, Dong J, Xu J, Zheng F, Zhou J, Zhao W, Lin Q, Ye L, Zhao X, Xu Z, Chen Y, Wang J, Wu W, Zhai L, Zhou Y, Zheng J, Zhang X. Effect of Mifepristone vs Placebo for Treatment of Adenomyosis with Pain Symptoms: A Randomized Clinical Trial. JAMA Netw Open. 2023;6(6):e2317860. [通信作者] (IF: 13.8)

13.Wang J, Xu P, Zou G, Che X, Jiang X, Liu Y, Mao X, Zhang X. Integrating Spatial Transcriptomics and Single-nucleus RNA Sequencing Reveals the Potential Therapeutic Strategies for Uterine Leiomyoma. Int J Biol Sci 2023; 19(8):2515-2530. [通信作者] (IF: 9.2)

14.Xu X, Wang J, Guo X, Chen Y, Ding S, Zou G, Zhu L, Li T, Zhang X. GPR30-mediated non-classic estrogen pathway in mast cells participates in endometriosis pain via the production of FGF2. Front Immunol. 2023;14:1106771. [通信作者]  (IF: 8.786)

15.Wang J, Xu P, Zou G, Yin M, Mao X, Zhang X. ROMA Index Is an Effective Predictor for Advanced Endometrial Cancer before Surgery. Dis Markers. 2022;2022:7409368. [通信作者] (IF:3.464).

16.Sun H, Yuan M, Wang X, Jiao X, Pan Z, Li H, Yang L, Wang L, Zhang S, Ren Q, Yan S, Li D, Zhang X, Wang G. Clinical efficacy and safety of trimonthly administration of goserelin acetate 10.8 mg in premenopausal Chinese females with symptomatic adenomyosis: a prospective cohort study. Gynecol Endocrinol. 2022 Dec 23:1-6. [共同通信作者] (IF: 2.277).

17.Chen S, Zhao M, Sun W, Zhu L, Zhang X. Investigation of the 12-month efficacy and safety of low-dose mifepristone in the treatment of painful adenomyosis. Reproductive and Developmental Medicine (RDM). 2022;6(3):152-161. [通信作者]

18.Li X, Zhang X, Shen Z, Chen Z, Wang H, Zhang X. GnRH receptor mediates lipid storage in female adipocytes via AMPK pathway. Int J Med Sci. 2022;19(9):1442-1450. [通信作者] (IF: 3.641)

19.Lin Q, Li T, Ding S, Yu Q, Zhang X. Anemia associated platelets and plasma prothrombin time increase in patients with adenomyosis. J Clin Med. 2022;11(15):4382. [通信作者] (IF: 4.964)

20.Xu X, Chen Y, Yu Q, Wang J, Xu P, Zhu L, Xu Q, Zhang J, Cui S, Yu K, Li T, Guo X, Zhang X. The presence of living endometrial cells in ovarian endometriotic cyst fluid may contribute to the recurrence of endometriosis after surgical excision of endometriomas. J Ovarian Res. 2022;15(1):89. [通信作者] (IF: 5.506)

21.Liu Y, Wang J, Zhang X. An update on the multifaceted role of NF-kappaB in endometriosis. Int J Biol Sci. 2022; 18(11): 4400-4413. [通信作者] (IF: 10.750)

22.Zhao M, Zhang M, Yu Q, Fei W, Li T, Zhu L, Yao Y, Zheng C and Zhang X. Hyaluronic Acid-Modified Nanoplatforms as a Vector for Targeted Delivery of Autophagy-Related Gene to the Endometriotic Lesions in Mice. Front Bioeng Biotechnol. 2022; 10:918368. [通信作者] (IF: 6.0644)

23.Zhou Y, Shen L, Wang Y, Yang M, Chen Z, Zhang X. Long term pregnancy outcomes of patients with diffuse adenomyosis after double-flap adenomyomectomy. J. Clin. Med. 2022; 11(12):3489. [通信作者] (IF: 4.964)

24.Xu P, Wang J, Zhang Y, Zhu L, Zhang X. Factors affecting the postoperative bowel function and recurrence of surgery for intestinal deep endometriosis. Front. Surg. 2022; 9:914661. [通信作者] (IF: 2.7182)

25.Yin M, Zhai L, Wang J, Yu Q, Li T, Xu X, Guo X, Mao X, Zhou J and Zhang X. (2022) Comprehensive Analysis of RNA-Seq in Endometriosis Reveals Competing Endogenous RNA Network Composed of circRNA, lncRNA and mRNA. Front Genet . 2022;13:828238. [共同通信作者] (IF:4.772)

26.Zhu L, Guan Z, Huang Y, Hua K, Ma L, Zhang J, Yang D, Perrot V, Li H, Zhang X. The efficacy and safety of triptorelin-therapy following conservative surgery for deep infiltrating endometriosis: A multicenter, prospective, non-interventional study in China. Medicine (Baltimore).2022;101(5):e28766. [通信作者] (IF:1.889).

27.Sun M, Xu P, Zou G, Wang J, Zhu L, Zhang X. Extrinsic Adenomyosis Is Associated With Postoperative Recurrence of Ovarian Endometrioma. Front Med (Lausanne). 2022;8:815628. [通信作者] (IF: 5.093)

28.Wang J, Xu P, Yang X, Yu Q, Xu X, Zou G, Zhang X. Association of Myometrial Invasion With Lymphovascular Space Invasion, Lymph Node Metastasis, Recurrence, and Overall Survival in Endometrial Cancer: A Meta-Analysis of 79 Studies With 68,870 Patients. Front Oncol. 2021;11:762329. [通信作者] (IF: 6.244)

29.Yu Q, Wang J, Li T, Xu X, Guo X, Ding S, Zhu L, Zou G, Chen Y, Zhang X. RON Mediates Tumor-Promoting Effects in Endometrial Adenocarcinoma. Biomed Res Int. 2021; 2021:2282916. [通信作者] (IF: 3.411)

30.Guo X, Xu X, Li T, Yu Q, Wang J, Chen Y, Ding S, Zhu L, Zou G, Zhang X. (2021) NLRP3 inflammasome activation of mast cells by estrogen via the nuclear-initiated signaling pathway contributes to the development of endometriosis. Front Immunol. 2021;12:749979. [通信作者]  (IF: 7.561)

31.Chen Z, Wang C, Lin C, Zhang L, Zheng H, Zhou Y, Li X, Li C, Zhang X, Yang X, Guan M, Xi Y. Lipidomic Alterations and PPARα Activation Induced by Resveratrol Lead to Reduction in Lesion Size in Endometriosis Models. Oxid Med Cell Longev. 2021; 2021:9979953. (IF: 6.543)

32.Chen B, Zhu L, Yang X, Wang W, Zhang X. Endometriotic Lesions on Uterine Scar. J Minim Invasive Gynecol. 2021; 28(8):1438-1439. [通信作者] (IF:4.134)

33.Sun W, Hua K, Hong L, Zhang J, Hao M, Wang J, Zhang J, Perrot V, Li H, Zhang X. Symptom control after different duration of triptorelin treatment following conservative surgery for deep infiltrating endometriosis: Post-hoc analysis of a multicentre, prospective, real-world study. Medicine (Baltimore). 2021; 100(30):e26753. [通信作者] (IF:1.889)

34.Zou G, Wang J, Xu X, Xu P, Zhu L, Yu Q, Peng Y, Guo X, Li T, Zhang X. Cell subtypes and immune dysfunction in peritoneal fluid of endometriosis revealed by single-cell RNA-sequencing. Cell Biosci. 2021; 11(1):98. [通信作者] (IF:7.133)

35.Ying X, Che X, Wang J, Zou G, Yu Q, Zhang X. CDK1 serves as a novel therapeutic target for endometrioid endometrial cancer. J Cancer 2021; 12(8):2206-2215. [通信作者]  (IF: 4.207)

36.Yu Q, Wang J, Li T, Guo X, Ding S, Che X, Zhu L, Peng Y, Xu X, Zou G, Zhang X. Recepteur d'origine nantais contributes to the development of endometriosis via promoting epithelial‐mesenchymal transition of a endometrial epithelial cells. J Cell Mol Med. 2021; 25(3):1601-1612.  [通信作者] (IF: 5.310)

37.Ding S, Guo X, Zhu L, Wang J, Li T, Yu Q, Zhang X. Netrin-1 participates in endometriosis-associated pain. Ann Transl Med. 2021; 9(1):29. [通信作者] (IF: 3.932)

38.Chen S, Wang J, Sun W, Zhu L, He J, Zhang X. Efficacy of the levonorgestrel-releasing intrauterine device is associated with different subtypes of adenomyosis: a retrospective study. Ann Transl Med 2020; 8 (21):1356. [通信作者] IF：3.932 

39.Li T, Wang J, Guo X, Yu Q, Ding S, Xu X, Peng Y, Zhu L, Zou G, Zhang X. Possible involvement of crosstalk between endometrial cells and mast cells in the development of endometriosis via CCL8/CCR1. Biomedicine & Pharmacotherapy 129 (2020) 110476. [通信作者] IF：6.545

40.Ding S, Yu Q, Wang J, Zhu L, Li T, Guo X, Zhang X. Activation of ATF3/AP-1 signaling pathway is required for P2X3-induced endometriosis pain. Hum Reprod. 2020;35(5):1130-1144. [通信作者] IF：6.933

41.Che X, Wang J, He J, Guo X, Li T, Zhang X. The new application of mifepristone in the relief of adenomyosis-caused dysmenorrhea. Int J Med Sci. 2020; 17(2):224-233. [通信作者] IF：3.738

42.Che X, Wang J, He J, Yu Q, Sun W, Chen S, Zou G, Li T, Guo X, Zhang X. A new trick for an old dog: The application of mifepristone in the treatment of adenomyosis. J Cell Mol Med. 2020; 24(2):1724–1737. [通信作者] IF:5.310

43.Zhou Y, Chen ZY, Zhang XM. Giant exophytic cystic adenomyosis with a levonorgestrel containing intrauterine device out of the uterine cavity after uterine myomectomy: A case report. World J Clin Cases. 2020;8(1):188-193. [通信作者] IF:1.337

44.Guo X, Ding S, Li T, Wang J, Yu Q, Zhu L, Xu X, Zou G, Peng Y, Zhang X. Macrophage-derived netrin-1 is critical for neuroangiogenesis in endometriosis, Int J Biol Macromol. 2020; 148:226-237. [通信作者]  IF: 8.025/Q1

45.Zou G, Xu P, Zhu L, Ding S, Zhang X. Comparison of subsequent pregnancy outcomes after surgery for adnexal masses performed in the first and second trimester of pregnancy. Int J Gynaecol Obstet. Int J Gynecol Obstet 2020; 148: 305–309. [通信作者] IF:3.651

46.Ding S, Lin Q, Zhu T, Li T, Zhu L, Wang J, Zhang X. Is there a correlation between inflammatory markers and coagulation parameters in women with advanced ovarian endometriosis? BMC Women's Health. 2019, 19(1):169. [通信作者] IF:2.809

47.Zhao MD, Li JQ, Chen FY, Dong W, Wen LJ, Fei WD, Zhang X, Yang PL, Zhang XM, Zheng CH. Co-Delivery of Curcumin and Paclitaxel by “Core-Shell” Targeting Amphiphilic Copolymer to Reverse Resistance in the Treatment of Ovarian Cancer. Int J of Nanomedicine. 2019:14; 9453–9467. [共同通信作者] IF:6.400

48.Baboo K, Chen Z, Zhang X. Role of Oxidative Stress and Antioxidant Therapies in Endometriosis. Reprod Dev Med, 2019,3(3): 170-176. [通信作者]

49.Zhu L, Chen S, Che X, Xu P, Huang X, Zhang X. Comparisons of the efficacy and recurrence of adenomyomectomy for severe uterine diffuse adenomyosis via laparotomy versus laparoscopy: a long-term result in a single institution. J Pain Res. 2019; 12:1917-1924. [通信作者] IF:3.133

50.Zhu TH, Zou G, Ding SJ, Li TT, Zhu LB, Wang JZ, Yao YX, Zhang XM. Mast cell stabilizer ketotifen reduces hyperalgesia in a rodent model of surgically induced endometriosis. J Pain Res. 2019; 12:1359-1369. [通信作者] IF:3.133

51.Dai Y, Zhang X, Xue M, Zhou Y, Sun P, Leng J. Not Having Been Breastfed May Protect Chinese Women From Developing Deep Infiltrating Endometriosis: Results From Subgroup Analyses of the FEELING Study. Reprod Sci. 2019; 26(8):1158-1167. IF:3.060

52.Dai Y, Zhou Y, Zhang X, Xue M, Sun P, Leng J, Chapron C. Factors associated with deep infiltrating endometriosis versus ovarian endometrioma in China: a subgroup analysis from the FEELING study. BMC Womens Health. 2018; 18(1):205. IF:2.809

53.Ding S, Zhu T, Tian Y, Xu P, Chen Z, Huang X, Zhang X. Role of Brain-Derived Neurotrophic Factor in Endometriosis Pain. Reprod Sci. 2018; 25(7):1045-1057.. [通信作者] IF:3.060

54.Zhu T, Ding S, Li T, Zhu L, Huang X, Zhang X. Estrogen is an important mediator of mast cell activation in ovarian endometriomas. Reproduction. 2018; 155(1):73-83.  [通信作者] IF:3.9.06

55.Yuan M, Ding S, Meng T, Lu B, Shao S, Zhang X, Yuan H, Hu F. Effect of A-317491 delivered by glycolipid-like polymer micelles on endometriosis pain. Int J Nanomedicine. 2017:12 8171–8183. IF:6.400

56.Ding S, Zhu L, Tian Y, Zhu T, Huang X, Zhang X. P2X3 receptor involvement in endometriosis pain via ERK signaling pathway. PLoS One. 2017; 12(9):e0184647.  [通信作者] IF:3.240

57.Xu P, Ding S, Zhu L, Le F, Huang X, Tian Y, Zhang X. Elevated RON protein expression in endometriosis and disease-associated ovarian cancers. Arch Gynecol Obstet. 2017; 295(3):631-639. [通信作者] IF:2.344

58.Li X, Shen B, Chen Q, Zhang X, Ye Y, Wang F, Zhang X. Antitumor effects of cecropin B-LHRH' on drug-resistant ovarian and endometrial cancer cells. BMC Cancer. 2016; 16(1):251. [通信作者]  IF:3.15

59.Zhang J., Zhu L., Huang X., Xu P., Chen Z., Huang Q., Zhang X. Mitochondrial DNA haplogroup R confers a genetic risk factor for intrauterine adhesion in Han women population. Gynecol Obstet Invest. 2016;81(3):238-43.  [通信作者]

60.Chapron C, Lang JH, Leng JH, Zhou Y, Zhang X, Xue M, Popov A, Romanov V, Maisonobe P, Cabri P. Factors and Regional Differences Associated with Endometriosis: A Multi-Country, Case-Control Study. Adv Ther. 2016 Aug;33(8):1385-407.

61.Huang X, Huang Q, Chen S, Zhang J, Lin K, Zhang X. Efficacy of laparoscopic adenomyomectomy using double-flap method for diffuse uterine adenomyosis. BMC Womens Health. 2015; 15(1):182. [通信作者]

62.Zhang XM, Huang X, Xu H, Quinn MJ. Altered innervation of the fallopian tube in adenomyosis. J Obstet Gynaecol.  2015; 35(3):319-20.

63.Che X, Liu X, Zhang X, Quinn M. Abnormal innervation of narrowed, uterine spiral arterioles in early pregnancy. J Obstet Gynaecol. 2014:35(1):88-9. 

64.Zhang X, Huang X, Xu H, Quinn M. Altered innervation of the fallopian tube in ectopic pregnancy. J Obstet Gynaecol. 2014; 34(6):531-2.

65.Zhu L, Huang Q, Huang X, Zhang J, Xu H, Zhang X. Decreased nerve fibers in the oviduct isthmus of women with endometriosis. Acta Histochem.  2014 Jun;116(5):871-7.  [通信作者] 

66.Sun Y, Zhu L, Huang X, Zhou C, Zhang X. Immunohistochemical localization of nerve fibers in the pseudocapsule of fibroids. Eur J Histochem. 2014; 58(2):2249. [通信作者]

67.Xu H, Yang Y, Caiyun Zhou C, Huang X, Lin J, Zhang X. Increased endometrial expression of CC-chemokine receptor-1 in women with adenomyosis. Histol Histopathol. 2014; 29(9):1153-60. [通信作者]

68.Che X, Huang X, Zhang J, Xu H, Zhang X. Is nerve-sparing surgery suitable for deeply infiltrating endometriosis? Eur J Obstet Gynecol Reprod Biol. 2014; 175:87-91. [通信作者]

69.Wang P, Zhu L, Zhang X. The role of placental protein 14 in the pathogenesis of endometriosis. Reprod Sci. 2013; 20 (12):.1465-1470. [通信作者]

70.Zhu L, Chen JX, Sun YM, Huang XF, Xu H, Zhang X. Loss of nerve fibers in the oviduct isthmus in women with hydrosalpinx. Acta Histochem. 2013; 115(6)609-615. [通信作者]

71.Feng C, Chen ZY, Zhang J, Xu H, Zhang XM, Huang XF. Clinical utility of serum reproductive hormones for the early diagnosis of ectopic pregnancy in the first trimester. J Obstet Gynaecol Res. 2013; 39(2):528-35.

72.Yang Y, Zhang X, Zhou C, Huang X, Lin J, Xu H. Elevated immunoreactivity of RANTES and CCR1 correlate with the severity of stages and dysmenorrhea in women with deep infiltrating endometriosis. Acta Histochem. 2013; 115(5):434-9. .

73.Fu G, Che X, Sun Y, Huang X, Xu H, Zhou C, Zhang X. Pigment epithelial-derived factor expression in endometriotic lesions in a rat model of endometriosis. Acta histochemica. 2013；115(4): 301-307.  [通信作者]

74.Zhang X, Huang X, Xu H, Quinn M. Endometriosis: a consequence of varying injuries to pelvic autonomic nerves. Fertil Steril. 2012; 98(6):e29. IF:6.31---5

75.Zhang X, Xu H, Zhang X, Zhou C, Huang X. Persistent endometriosis of the right inferior hypogastric nerve.  J Obstet & Gynaecol. 2012; 32(8):813-813.

76.Sun Y, Che X, Zhu L, Zhao M, Fu G, Huang X, Xu H, Hu F, Zhang X. Pigment epithelium derived factor inhibits the growth of human endometrial implants in nude mice and of ovarian endometriotic stromal cells in vitro. PLoS ONE 2012; 7(9): e45223.  [通信作者]

77.Huang X, Chen L, Fu G, Xu H, Zhang X. Decreased expression of pigment epithelium-derived factor and increased microvascular density in ovarian endometriotic lesions in women with endometriosis. Eur J Obstet Gynecol Reprod Biol. 2012; 165 (1):104-109.  [通信作者].

78.Chen L, Fan R, Huang X, Xu H, Zhang X. Reduced Levels of Serum Pigment Epithelium-Derived Factor in Women With Endometriosis. Reprod Sci. 2012; 19(1):64-69.  [通信作者].

79.Zhao MD, Sun YM, Fu GF, Du YZ, Chen FY, Yuan H, Zheng CH, Zhang XM, Hu FQ. Gene therapy of endometriosis introduced by polymeric micelles with glycolipid-like structure. Biomaterials. 2012;33 (2):634-43. [通信作者]. IF: 12.479---6

80.Fan R, Qiu L, Huang X, Chen Z, Xu H, Zhou C, Zhang X. Increased Nerve Fibers in Placental bed Myometrium in Women with Preeclampsia. Reprod Sci. 2011; 18 (12): 1262-1266.  [通信作者].

81.Chen L, Fan R, Huang X, Xu H, Zhang X. Decreased concentrations of pigment epithelium-derived factor in peritoneal fluid of patients with endometriosis. Fertil Steril. 2011;95(5):1798-800. [通信作者] IF:6.31---7

82.Lasmar RB, Xinmei Z（hang）, Indman PD, Celeste RK, Di Spiezio Sardo A. Feasibility of a new system of classification of submucous myomas: a multicenter study. Fertil Steril. 2011;95(6):2073-7. 1. IF:6.31---8

83.Zhang X, Lu B, Huang X, Xu H, Zhou C, Lin J. Innervation of endometrium and myometrium in women with painful adenomyosis and uterine fibroids. Fertil Steril. 2010;94(2):730-7.  IF:6.31---9

84.Zhang X, Qi C, Lin J. Enhanced expressions of matrix metalloproteinase (MMP)-2 and -9, vascular endothelial growth factors (VEGF), and increased microvascular density in endometrial hyperplasia of women with anovulatory dysfunctional uterine bleeding. Fertil Steril. 2010;93 (7):2362-7. IF:6.31---10

85.Ruan F, Lin J, Wu RJ, Xu KH, Zhang XM, Zhou CY, Huang XF. Phosphatase of regenerating liver-3: a novel and promising marker in human endometriosis. Fertil Steril. 2010;94(6):1980-4. IF:6.31---11

86.Zhang X, Yao H, Huang X, Lu B, Xu H, Zhou C. Nerve fibers in ovarian endometriotic lesions in women with ovarian endometriosis. Hum Reprod. 2010;25(2):392-7.  IF:5.75---12

87.Zhang X, Lu B, Huang X, Xu H, Zhou C, Lin J. Endometrial nerve fibres in women with endometriosis, adenomyosis and uterine fibroids. Fertil Steril. 2009; 92(5):1799-801. IF:6.31---13

88.Lin K Zhu X, Hong Xu, Liang Z, Zhang X. Reproductive outcome following resectoscope metroplasty in women having a complete uterine septum with double cervix and vagina. Int J Gynaecol Obstet. 2009; 105(1):25-8. [通信作者]

89.Zhang X, Yuan H, Deng L, Hu F, Ma J, Lin J. Evaluation of the efficacy of a danazol-loaded intrauterine contraceptive device on adenomyosis in an ICR mouse model. Hum Reprod. 2008; 23(9): 2024–2030. IF:5.75---14

90.Zhang X, Wen J, Deng L, Lin J. (2007) Decreased levels of peritoneal interleukin-1 receptor antagonist in patients with endometriosis and the disease-related dysmenorrhoea. Fertil & Steril. 2007;88(3):594-9. IF:6.31---15

91.Zhang X, Hei P, Deng L, Lin J. (2007) IL-10 gene promoter polymorphisms and their protein production in the peritoneal fluid in patients with endometriosis. Mol Hum Reprod,  2007;13(2):135-140.

92.Lin J, Zhang X, Deng L, Fang Q, Qian Y. Decreased peritoneal concentrations of interleukin-15 in women with advanced stage endometriosis. European Journal of Obstetrics & Gynecology and Reproductive Biology, 2006; 129 (12):169-173. [通信作者]

93.Lin J, Zhang X, Deng L, Fang Q, Qian Y. (2006) Decreased peritoneal concentrations of interleukin-15 in women with advanced stage endometriosis. Presenting in.(2006.9) XVIII FIGO World Congress of Obstetrics & Gynecology. 通信作者]

94.Zhang X. Traditional Chinese medicine and Laparoscopic Surgery for the management of endometriosis. APEA Newletter March, 2006 and NZEF Newsletter May, 2006.

95.Zhang X, Xu H, Lin L, et al. Peritoneal fluid concentrations of interleukin-17 correlate with the severity of endometriosis and infertility of this disorder. BJOG., 2005; 112(8):1153-1155. [通信作者] IF:4.75

96.Zhang X, Lin,J Deng L. Peritoneal and serum IL-16 concentrations in women with endometriosis.  Acta Obstetricia et Gynecologica Scandinavica, 2005;84(3):297-299. [通信作者]

97.Zhang X, Liu X, Fang H. Interstitial pregnancy and transcervical curettage. Obstet.  Gynecol., 2004; 104 (supple1):1193-1195. [通信作者] IF:6.3---16

98.Zhang X, Lin J, Deng L. Decreased levels of IL-18 in peritoneal fluid but not in serum of women with endometriosis. Fertil. Steril., 2004;81(5):1229-1234. IF:6.31---17

99.Lin J, Zhang X, chen Y. Mutagen Sensitivity as a Susceptibility Marker for Endometriosis. Hum. Reprod., 2003; 18(9):2052-2057. [通信作者] IF:5.75---18

100.Lin J, Zhang X, Qian Y, et al.  Glutathione S- transferase M1 and T1 genotypes and endometriosis risk: a case-controlled study. Chin. Med. J. 2003; 116(11):777-780. [通信作者]

101.Lin J, Zhang X, Xu K. Application of ultrasonic scalpel in gynecologic operative laparoscopy.  Chin. Med. J.,  2001;114(9):1283-1285. [通信作者]

102.Schabath MB, Spitz MR, Zhang X, Delclos GL, Wu X. Genetic variants of myeloperoxidase and lung cancer risk. Carcinogenesis, 2000;21(12):1163-1166. IF:5.75---19.

2、中文期刊

1.徐萍, 张亚男,尤冰冰, 邹亘, 张信美. 妊娠合并子宫腺肌病患者胚胎着床部位与病灶位置的关系对妊娠结局的影响[J].中华妇产科杂志, 2021,56(12):858-862. [IM收录，通信作者]

2.张信美. 重视子宫腺肌病患者生育的全程管理.中华妇产科杂志, 2020,55( 12 ): 167-171. (述评)

3.张信美, 徐萍. 子宫腺肌病分层治疗及管理. 浙江大学学报（医学版）.2019, 48 (2): 123-129.

4.BabooKalianee Devi,陈正云,张信美. 子宫腺肌病患者药物治疗进展. 浙江大学学报（医学版）. 2019, 48 (2): 142-147.

5.林巧, 丁少杰, 竺天虹, 李田田, 黄秀峰, 张信美. 凝血和炎症因子在中重度卵巢子宫内膜异位症发病中的作用及临床诊断的意义. 中华妇产科杂志,2018,53( 3 ): 167-171. [IM收录，通信作者]

6.陈正云,赵立,阿斯燕·努斯拉提,赵达,周密, 张信美. 剖宫产术后子宫瘢痕妊娠实施子宫病灶切除术与子宫切除术的临床对比分析. 中华妇产科杂志. 2017;52(2):98-102. [IM收录，通信作者]

7.陈正云, 赵立, 李小永, 阿斯燕·努斯拉提, 徐萍, 张信美. 子宫切除终止高危剖宫产瘢痕部位妊娠的临床分析. 中华急诊医学杂志. 2017, ( 11): 1327-1329. [IM收录，通信作者]

8.陈正云, 李小永, 赵达, 周密, 徐萍, 黄秀峰, 张信美. 宫腔镜手术终止早期Ⅱ型剖宫产术后子宫瘢痕妊娠的临床研究. 中华妇产科杂志. 2017, (10): 669-674. [IM收录，通信作者]

9.朱丽波, 丁少杰, 竺天虹, 黄秀峰, 张信美. 子宫内膜异位症患者异位内膜和在位内膜组织中P2X3的表达及其意义. 中华妇产科杂志. 2017, (4): 264-267. [IM收录，通信作者]

10.裘琳, 黄秀峰, 张信美. 醋酸棉酚宫内给药装置治疗子宫腺肌病实验研究. 中国实用妇科与产科杂志., 2017, (2) :209-213. [ 通信作者]

11.陈舒宜, 孙文婷, 朱丽波, 丁少杰, 徐萍, 黄秀峰, 张信美. 不同低剂量米非司酮治疗子宫腺肌病伴痛经患者的疗效研究. 现代妇产科进展.  2016, (25):881-885.[ 通信作者]

12.林开清, 朱丽波, 张信美, 林俊. 肥大细胞在雌激素介导的子宫内膜异位症模型中的作用机制研究. 浙江大学学报（医学版）, 2015; 44(3):269-277. [IM收录，通信作者]

13.朱丽波, 林开清, 张信美,林俊. 色甘酸钠对子宫内膜异位症大鼠肥大细胞功能的调节作用. 浙江大学学报（医学版）, 2015; 44(3):278-284. [IM收录，通信作者]

14.黄琼施,黄秀峰,张晶,朱丽波, 张信美. 双瓣改良弥漫性子宫腺肌病病灶切除术的疗效观察. 实用妇产科杂志. 2014; 30:605-608. 

15.陈君霞，张信美. 腹腔镜下输卵管切除术后持续性异位妊娠11例临床分析. 中国实用妇科与产科杂志.2014. 1.  67-70

16.车璇, 张晶, 张信美. 中重度子宫内膜异位症患者行腹腔镜下保守手术后应用促性腺激素释放激素激动剂的治疗效果. 上海医学. 2013; 36(5):457-460.

17.王萍，朱丽波，苏琴芬，张信美. 胎盘蛋白14在子宫内膜异位症发病中作用的初步探讨. 中国实用妇科与产科杂志. 2013. 5. 364-367

18.孙艳美,付国芳,许泓,黄秀峰,张信美. 改良法建立大鼠深部浸润型子宫内膜异位症模型. 中国医科大学学报. 2012; 41(2):101-103.

19.付国芳, 孙艳美, 黄秀峰, 张信美. 子宫内膜异位症SD大鼠模型不同部位异位病灶生长特点分析. 现代妇产科进展. 2011; 20(8):256-258.  

20.姚慧娇，黄秀峰，卢邦春，周彩云，张晶，张信美. 子宫内膜异位症患者腹膜病灶中神经蛋白基因产物9.5的表达及其临床意义. 中华妇产科杂志. 2010，45（4）：256-259. [通信作者]

21.黄秀峰, 韩婵娜, 林开清, 张晶, 许泓, 张信美. 超声检查对深部浸润型子宫内膜异位症诊断价值的荟萃分析. 中华妇产科杂志. 2010，45（2）：260-265. [通信作者]

22.林开清，黄秀峰，张信美，舒淑娟. 宫腔镜电切术治疗部分性胎盘植入七例临床分析.中华妇产科杂志. 2010，45（2）：145-147. [通信作者]

23.张信美,许泓,黄秀峰,张晶,林俊. 左旋18甲基炔诺酮缓慢释放系统治疗子宫腺肌病的长期疗效观察. 中华妇产科杂志, 2009;44(9) :694-696.

24.卢邦春 黄秀峰 周彩云 许泓 林俊 张信美. 子宫腺肌病患者子宫内膜神经纤维的分布及其临床意义. 中华妇产科杂志, 2009;44(5) :324-7. [IM收录，通信作者]

25.何佩 林俊 张信美 邓琳 马俊彦. 白细胞介素-10基因启动子多态性与子宫内膜异位症遗传易感性的相关性. 遗传, 2009, 31(5): 479-484.

26.赵瑾, 林俊, 张信美.子宫内膜息肉中Bcl-2、Bax和Caspase3表达及其意义. 中国妇幼保健, 2009, 23(25):3579-3582.

27.卢帮春, 张信美. 子宫内膜异位症患者血脂和钙磷代谢的变化及其临床意义. 中华妇产科杂志, 2008;43(3) :185-8. [IM收录，通信作者] 

28.林开清, 许泓, 梁章霞, 张信美. 宫腔镜电切割治疗伴双宫颈和阴道纵隔的完全性纵隔子宫的妊娠结局分析. 中华妇产科杂志, 2008;43 (11):849-851. [通信作者]

29.林开清, 范华光, 许泓, 张信美. 疑难间质部妊娠的诊治探讨. 浙江大学学报（医学版）, 2008; 37(6):638-41. [IM收录，通信作者]

30.许泓, 陈雪珍, 林俊, 张信美. 子宫黏膜下肌瘤新分级评分法对宫腔镜电切割术的指导意义. 中华医学杂志. 2008 Jan; 88(1):22-24. [IM收录，通信作者]

31.叶轶青,林俊,张信美,杨峰亮,虞和永. 反相高效液相色谱法测定大鼠血浆及子宫组织中达那唑的药物浓度. 药物分析杂志, 2008, 28(2):216-218.

32.楼卓鑫, 张信美. 卵巢平滑肌瘤1例报道并文献复习. 浙江医学， 2008，30（2）：177-178.

33.张信美, 邓琳, 马俊彦, 林俊,等. 携带丹那唑宫内节育器治疗小鼠子宫腺肌病的研究. 浙江预防医学杂志,  2007; 19(9):1-3.

34.张信美,邓琳,马俊彦,林俊. 异体垂体移植诱发ICR小鼠子宫腺肌病动物模型的建立. 现代妇产科进展, 2007; 16(4):294-296.

35.楼卓鑫, 张信美. 围绝经期子宫内膜息肉361例临床分析. 现代妇产科进展, 2007; 16(8):631-632. 

36.徐冬,张信美,赵小环,陈小君. 输卵管切除术后持续性宫外孕2例分析. 现代妇产科进展, 2007; 16(11):972-973.

37.温洁,邓琳,张信美,林俊. 白细胞介素-1受体拮抗剂与子宫内膜异位症的关系. 浙江预防医学杂志,  2006; 18(6):15-17

38.温洁,张信美,邓琳,林俊. 子宫内膜异位症患者白细胞介素1受体拮抗剂水平的变化及其意义. 中华妇产科杂志, 2005;41(9):536-538.

39.温洁, 邓琳, 张信美,林俊. 白细胞介素-1家族基因多态性与子宫内膜异位症的相关性研究. 浙江大学学报（医学版）. 2006; 35(6)653-657.

40.张信美,,胡东晓,张琴芳,林俊. 子宫肌瘤合并腹水伴妊娠1例报道 . 中华妇产科杂志, 2005;40(11):648.

41.陈正云,陈志文,林俊,张信美,徐开红. 影响宫腔镜诊断子宫内膜息肉的相关因素探讨. 现代妇产科进展, 2005; 14(4):300-303. 

42.张信美,林俊,许鸿,邓琳,钱羽力.子宫内膜异位症患者腹腔液中白细胞-17水平的测定及其意义.中华妇产科杂志, 2005;40(7):380-382. [IM]

43.林俊,张信美,邓林.子宫内膜异位症患者腹腔液中白细胞-16水平的测定. 浙江大学学报(医学版), 2005;34(6):260-262. [IM]

44.张信美,谢臻蔚, 金杭美. 女童生殖系统急性疾病102例分析. 中华急诊医学杂志   2003;12(9):550-551.

45.金杭美,张信美, 郑斐. 单纯子宫切除术后血清FSH及E2水平的变化. 中华内分泌代谢杂志,2002;18(10):450-452.

46.林俊,张信美,陈玉兰,石一复,徐开红. 博莱霉素诱导子宫内膜异位症患者淋巴细胞染色单体断裂的研究.  中华妇产科杂志, 2002;37(9):561-562.

47.林俊,张信美,钱羽力,等. 子宫内膜异位症患者谷胱甘肽S-转移酶M1和T1基因缺失的检测.  中华妇产科杂志, 2002;37(6):370-371.

48.林俊,张信美,徐开红. 超声刀在妇科腹腔镜手术中的应用.  中华妇产科杂志, 2001;36(9):568-569.

49.张信美,林俊, 徐开红.  宫腔镜电切术治疗异常子宫出血的研究.  中华妇产科杂志, 2000;35(12):31-33. [IM]

50.张信美, 石一复.子宫腺肌病206例临床分析. 中华妇产科杂志., 1998; 33(7): 434-435.

51.张信美, WU Xifeng. 绿茶提取液对苯并(a)芘二羟环氧化物致染色单体断裂的修饰作用. 浙江大学学报(医学版), 2002;31(6):474-476.

52.张信美,王曼. 异位子宫内膜和在位子宫内膜分泌泌乳素的研究.  浙江医科大学学报, 1997;25(8):251-252.

53.陈正云, 林俊, 张信美. 宫腔镜术后子宫内膜息肉复发危险因素分析. 中国现代手术学杂志, 2004;8(3):19-22.

54.陈黎,林俊,张信美.  血清CA(125)和PRL测定对子宫腺肌病的诊断价值.  浙江预防医学, 2003;26(8):153-155.   

55.张信美,石一复,林俊. 输卵管子宫内膜异位症21例临床分析.   现代妇产科进展, 2002;11(10):265-267.

56.张信美,石一复. 子宫腺肌症患者子宫次全切除术后的危险性探讨.  现代妇产科进展, 2001;10(6):120-122. 

57.Zhang XM, Shi YF. Is subtotal hysterectomy suitable for the patients with adenomyosis?  CMJ Network,  2001 (in English).

58.Zhang XM, Wu X. Modification of Lung Cancer Susceptibility by Green Tea.  CMJ Network, 2000 (in English).

59.张信美, 顾佩宝.妊娠急性脂肪肝的早期诊断. 浙江预防医学, 2000;23(6):36-38.

60.贺晶，张信美. 妊高征致宫内生长受限的相关因素分析.  中国实用妇科与产科杂志, 1998;23(7):34-35.

61.张信美,王曼. 子宫内膜异位症患者泌乳素分泌功能的研究.浙江医学, 1997;148(3):168-170.

……

二、成果奖励： 

1.《子宫内膜异位症疼痛新机制及调控策略》》获2020年浙江省自然科学二等奖.张信美等. (1/5).

2.《子宫腺肌症精准诊疗体系的构建及推广应用》获2021年妇幼健康科学技术奖科技成果奖三等奖.张信美等. (1/8)

3.《子宫腺肌病的发病机制和临床特征研究》获2013年浙江省医药卫生科技奖一等奖. 张信美等.(1/8)

4.《白细胞介素在子宫内膜异位症中的表达及其临床意义》获2007年教育部科技进步奖二等奖. 林俊, 张信美等. （2/8）

5.《子宫内膜异位症的发病和癌变机制以及临床特征》获2005年浙江省科学技术二等奖.林俊, 张信美,等. (2/10)

三、承担课题： 

1.谷氨酸/受体轴介导肥大细胞协同致子宫内膜异位症疼痛敏化的机制研究。国家自然科学基金 82471682  70万  2025.1.1-2028.12.31  负责人张信美

2.子宫内膜异位症国家级数据平台建设和综合防治策略研究。子课题三（子宫腺肌病影像学分型和分子分型及其防治研究）（2022YFC2704003）222.5万 （135万）  2023.1-2025.12  负责人张信美

3.MRGPRX2/B2激活肥大细胞致子宫内膜异位症疼痛敏化的分子机制研究。国家自然科学基金 82171636  55万  2022.1-2025.12  负责人张信美 

4.Netrin-1促进子宫内膜异位症发生发展及其介导疼痛敏化的作用机制研究. 国家自然科学基金 81974225   53万 2020.1-2023.12  负责人张信美

5.子宫内膜异位症病因学与临床防治研究。国家重大专项（SQ2017YESF080001）课题（肥大细胞在子宫内膜异位症发生发展中的作用机制）。300万。 2018-2021  负责人张信美

6.RON介导的上皮-间质转换在子宫内膜异位症发生发展中的作用机制研究。国家自然科学基金 81671429   57万 2017.1-2020.12  负责人张信美

7.ATP和P2X3受体参与雌激素调节子宫内膜异位症疼痛信号转导通路的作用及机制研究。国家自然科学基金81471433  74万 2015.1-2018.12  负责人张信美

8.MAPK/CREB信号转导通路与子宫内膜异位症疼痛敏化调控机制研究. 国家自然科学基金81270672  70万 2013.1-2015.12  负责人张信美

9.微创妇科学   2011-2013. 浙江省重点医学科学 （创新学科） 30 万.负责人张信美

10.新型超声宫腔镜内镜系统的整机研究  浙江省科学重大专项 (2011C13028-1)  75万 2011-2013，负责人张信美

11.MAPKCREB信号通路在子宫内膜异位症疼痛中的作用及其分子作用机制。 浙江省自然基金 Y2110181  6万 20010.1-2012.12  负责人张信美

12.糖脂纳米载体介导PEDF治疗子宫内膜异位症的疗效及其机制研究. 国家自然科学基金81070468  32万 2010.1-2012.12  负责人张信美

13.雌激素调控子宫内膜异位症病灶神经分布致疼痛的机理研究. 国家自然科学基金30872754  8万 2009.1-2009.12  负责人张信美

14.子宫内膜异位症疼痛神经分布和信号传导的研究。 浙江省自然基金 Y2080123 8万 2009.1-2011.12  负责人黄秀峰，排名第二

15.RANTES/CCR1径路对子宫内膜异位症形成的机理研究.  浙江省自然基金 Y2080343 8万 2009.1-2011.12  负责人许泓，排名第二

16.醋酸棉酚阴道给药治疗深部浸润型子宫内膜异位症的研究. 浙江省科技厅 2007C23015 20万 2007.4-2009.12. 负责人张信美.

17.醋酸棉酚新宫内给药途径治疗子宫腺肌病的开发研究. 省科技厅(钱江人才计划） 2006R10027  10万  2007.1-2009.12  负责人许泓，排名第二.

18.抗肿瘤靶向药物Cecropin B-LHRH'重组基因的构建表达及抑癌功能研究. 国家自然科学基金（青年科学基金） 30700896  18万 2008.1-2010.12  负责人李小永，排名第二.

19.恶英诱导离体子宫内膜间质细胞细胞因子表达的研究. 浙江省教育厅 20040237 1万 2004.7-2006.7  负责人张信美.

20.Danazol-loading-IUD治疗子宫腺肌病的推广应用. 浙江省卫生厅  2004tg021万 2004.7-2006.7  负责人张信美.

21.IL-18与子宫内膜异位症发病危险性关系的研究. 浙江省卫生厅 2003a1077 1 万  2004.1-2006.12  负责人张信美.

22.丹那唑宫内给药装置治疗子宫腺肌病的实验研究. 浙江省科技厅  10万  2004.7-2006.12  负责人林俊，排名第二.

23.异常子宫出血的基础和临床研究. 浙江省卫生厅重点项目  10万 2004.1-2006.12负责人林俊，排名第二.